For nearly 200 years physicians have been limited in their detection of ocular disease by the reliance on the utilization of vision measured with a chart and examination of the eye performed by the physician with lenses. We have now come to realize that both methods fail to demonstrate the early onset of ocular disease and follow the advance of ocular pathology with therefore only poor improvement in functional vision when treatment is applied far too late in the course of the disease progression. Physicians are in desperate need of devices that will detect ocular disease and functional vision impairment earlier in the course, better assess the impact of treatment, and assist in monitoring for recurrence or progression that may require retreatment. Furthermore, such devices must be tied into a centralized, informative database that provides the physician sequential comparisons over time in order to, not only assist in the screening for disease, but also provide for the individual patient risk prediction for assessing progression as well as the response to treatment. These have been the goals of devices as well as ocular treatments pursued by Sinclair Technologies, LLC.